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Chelsea Handler did an episode on her short-lived TV show about her ayahuasca experience, including footage of the group being crazy high and vomiting in buckets. Unlike the friends who came with her, Chelsea's done a lot of drugs, and the initial dose didn't affect her at all, so she had to come back and get a "shaman-level" brew. She described having an overall good experience with it, though if I recall correctly at least one of her friends suffered a bad trip and hallucinated scary shit she didn't want to confront.
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