Well Mike, if you're looking for full-blown danger, Temple it is.
Seriously though, from my experience, a lot of good schools have been in shady or semi-shady areas. In most cases, these schools have excellent security, such as Temple and St. Louis University. Or, as long as you stay on or near campus, you'll be alright (Penn, Drexel, Univ. of Illinois-Chicago).
I agree with UT--Drexel definitely kicks ass, so long as you stay south of Lancaster Ave., and east of 38th St.