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An overdose is taking too much of anything. Technically this does include taking more than the recommended dosage of something. In that sense I regularly "overdose" on Ibuprofen ... because I take 600-800 mg at a time and the reccommended OTC dosage is 400 mg. This is actually a bit misleading, because the real level of overdose for Ibuprofen is (scratches head) 2400 mg/day? But, I don't take it every day, and prescription dosage for ibuprofen is usually 600 mg.
To die of an overdose, it has to be the action of the substance itself ... you die from too much heroin because you have too much heroin in your system. Same for alcohol. It's more like poisoning.
You die from crack because your heart explodes.
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