For DOS/Windows, presumably?
The one I used for years was NESticle, but according to <a href="http://www.zophar.net/nes.html">Zophar's Domain</a> (a good emu site), it's now outdated. I've used the Dreamcast version of Nester, which was good, as well as a port of fwNES, so I'd say that either NNNesterJ or FCE Ultra (PC versions of the above, linked at Zophar's above) would be worth looking into.
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