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Reasons for Palin's resignation are due to a cacophony of details - quoted here in the same disjointed way that those details have apparently conspired to change her life. From the NY Times of 12 Jul 2009:

Palin’s Route to Resignation: Missteps and Ignored Advice
Sarah Palin was beset by such political and personal turmoil that some powerful supporters determined an intervention was needed to pull her governorship, and her national future, back from the brink. ...

Nick Ayers, arrived with a memorandum containing firm counsel, ... Make a long-term schedule and stick to it, have staff members set aside ample and inviolable family time to replenish your spirits, and build a coherent home-state agenda that creates jobs and ensures re-election. ... it appeared to be happily received and then largely discarded, ...

Almost as soon as she returned home, the once-popular governor was isolated from an increasingly critical Legislature. Lawmakers who had supported her signature effort to develop a natural gas pipeline turned into uncooperative critics.

Ethics complaints mounted, and legal bills followed. At home Ms. Palin was dealing with a teenage daughter who had given birth to a son and broken up with the infant’s father, a baby of her own with special needs and a national news media that was eager to cover it all.

Friends worried that she appeared anxious and underweight. Her hair had thinned ... Yet to the dismay of some advisers, Ms. Palin dived into the fray, seeming to relish the tabloid-ready fights ... his assertion that Ms. Palin had known the unwed high-schoolers were having sex all along. ...

But now, Ms. Palin had fewer defenders to lend support. ... Her growing list of detractors quickly signaled that they were not impressed with her celebrity status. ... When Ms. Palin made it back to Alaska in November, the state that had once given her an 83 percent approval rating was no longer so enchanted. ...

By all accounts, Ms. Palin became consumed with the complaints, no matter how small-bore — which many were — or where they came from. ... “Ethics Complaint on Governor’s Apparel Dismissed.” ... a Republican lawmaker, State Representative Mike Hawker, to accuse Ms. Palin of underfinancing sexual abuse programs.

... the swine flu, Ms. Palin skipped a briefing for administration officials on the outbreak by her chief medical officer, ... at the time the governor was meeting with top staff on the issue of federal stimulus funds. ...

Amid all the turmoil, Ms. Palin’s enthusiasm for the job itself seemed to be waning, her office appointment books from January 2007 through this May indicate. Since her return from the national campaign her days have typically started later and ended earlier, and the number of meetings with local legislators and mayors has declined.

... Paparazzi regularly stalked the family, once ambushing Bristol Palin ... If Bristol Palin was avoiding the limelight, her estranged boyfriend was seeking it. ...

Barbara Walters and Oprah Winfrey’s producer called with interview requests. She fielded lucrative book deals, ultimately accepting one estimated to be in the millions of dollars. A veteran television producer proposed a “West Wing” meets “Northern Exposure” reality show about her. Out-of-state political trips were flashbacks to the presidential campaign. Crowds chanted, “Run, Sarah, Run!”

... she expressed concern about her personal finances and complained that whenever she left Alaska “there was tremendous criticism up there.” ... the Palins seemed unprepared for the national stage. “I don’t think they got it, that they were in the arena,” ...

While the defense fund has raised more than $250,000, according to its trustee, the money cannot be spent pending resolution of an ethics complaint that contends that the contributions could amount to improper gifts. ...

Mr. Malek said he told Ms. Palin that “you have got to set up a mechanism so you can return calls.” “You are getting a bad rap,” ... “Important people are trying to talk to you. And she said, ‘What number are they calling?’ She did not know what had been happening.” ...

Hope for the intervention’s success soon faded. Despite advice to stick close to home and focus on an Alaska agenda, the governor accepted an invitation to attend an anti-abortion dinner in Indiana in April, even though the state budget was hanging in the balance in the Legislature.

When Tom Wright, chief of staff for the speaker of the Alaska House, suggested that the governor would catch heat for leaving, Ms. Palin stormed into his office and, according to a person familiar with the conversation, “proceeded to ream him out.”

One other factor apparent in all these examples is a disconnect between Palin and her staff. They appear to be somewhat uninformed and therefore largely disorganized.