*Steers were initially fed a barley silage-based diet, followed by transition to a barley grain-based diet.
*Despite not being administered antibiotics prior to arrival at the feedlot, the prevalences of steers shedding TET- and ampicillin (AMP)-resistant E. coli were >40 and <30%, respectively.
*Irrespective of treatment, the prevalence of steers shedding TET-resistant E. coli was higher in animals fed grain-based compared to silage-based diets.
*All steers shed TET-resistant E. coli at least once during the experiment. ("All" includes control group ie. no antibiotics)
*The findings of the present study indicated that subtherapeutic administration of tetracycline in combination with sulfamethazine increased the prevalence of tetracycline- and AMP-resistant E. coli in cattle.
However, resistance to antibiotics may be related to additional environmental factors such as diet.
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