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MP3 is the most useable. If there's some slim chance you'll turn into an audio weenie, and don't mind the harddrive space and download time, go with FLAC + MP3. Otherwise MP3 only.
AAC/Apple Lossless/MP3 HD will give you more compatibility issues. FLAC is easy to find programs that support on all platforms, but is (to my ears) overkill.
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