I-90 will take you to Cleveland, where you'll head south and end up on I-71. Coming back, if you take the turnpike you'll brush past the north side of Pittsburgh and carry on to Philly.
I haven't been to Cinci but have been all over north- and mid-Ohio as far as Columbus.
Unfortunately, I'm not enroute but am 35 miles south of where you'll pass through Erie, PA (lived there for several years). Grab either a Starbucks or a Krispy Kreme coffee on your way through and think of me.