There's a real tonal shift with Smith. His first couple of series have a kind of dark fairytale feel to them. The thing about Amy is that to all intents and purposes the Doctor's always been in her life. From the little girl, to much later.
Allows room for some interesting stories and new relationships. There's something almost paternal in the Doctor's relationship with Amy.
Out of interest, how far along Smith's run are you?
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