[monster]

Gane 42 is not the answer to life, the universe and everything.
first attempt: 748. many early vowels force many 3 letter words

can't be bothered to format, if you really care about the word, here they are;
-1: e. Letter not used.+19: sear. 5 Points +1.5x Word Length. +2.5x Multiplier. +42: hew. 17 Points +2.5x Multiplier. +42: haw. 17 Points +2.4x Multiplier. +223: quin. 62 Points +1.5x Word Length. +2.4x Multiplier. +26: far. 11 Points +2.3x Multiplier. +12: oil. 5 Points +2.3x Multiplier. +16: ram. 7 Points +2.3x Multiplier. +20: gam. 9 Points +2.2x Multiplier. +32: vat. 15 Points +2.2x Multiplier. +11: oar. 5 Points +2.1x Multiplier. +28: dust. 9 Points +1.5x Word Length. +2.1x Multiplier. +45: wire. 15 Points +1.5x Word Length. +2.0x Multiplier. +57: liker. 15 Points +2.0x Word Length. +1.9x Multiplier. +18: fie. 10 Points +1.8x Multiplier. +15: tine. 6 Points +1.5x Word Length. +1.7x Multiplier. +8: one. 5 Points +1.6x Multiplier. +89: jin. 59 Points +1.5x Multiplier. +6: nee. 4 Points +1.4x Multiplier. +13: tub. 10 Points +1.3x Multiplier. +5: lie. 4 Points +1.2x Multiplier. +11: fie. 10 Points +1.1x Multiplier. +11: anus. 7 Points +1.5x Word Length.