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According to the book it all has to do with what is happening hormonally during gestation.
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Evidently, we all start out as female until enough testosterone is created in the womb to have its masculine effect. Androgen, oestrogen and testosterone (the latter is an androgen) all seem to play roles in determining both sex and sexual orientation (at least before culture starts playing a role).
I think the most interesting thing about sexual orientation is that it's probably not as rigidly established as most might think. I have a lot of gay friends both male and female and I've always joked with them how they have a little "woman" or "man" in them respectively. I consider myself masculine, but when my friends see my collection of retro kitchen appliances, I say "There must be a little "gay" in me. It's both a form of stereotyping and acknowledging that our sexual orientation, at least biologically, is probably the result of a ratio of hormones at any given time. The latter is important because we produce them ourselves, so that ratio will change as we age.