Vaccination & epidemic

[TheMercenary]

I respect your views but you are not going to win converts by linking Huffington Post to any valid review of any medical issue. Just my 2 cents.

[jinx]

The full manuscript has not been published yet. The abstract is available in the Annals Of Epidemiology, Sept 2009. It costs $36 or so to view it online... I didn't think anyone would bother, but the information is worth noting regardless of your personal politics.

[TheMercenary]

Understood. I may be able to get it for free. Give me a few days and if I get it I may need to send it to you via EM.

[jinx]

Sweet. Thanks.

[TheMercenary]

Damm. Which one is it that you want?

I see a number of linked articles.

Can you send me the links of the ones you want?

Just post them here.

[jinx]

It's just the abstract...

Annals of Epidemiology Sept 2009: 19(9); 659
Hepatitis B Vaccination of Male Neonates and Autism

[TheMercenary]

Got it. Give me till early next week. I have a busy next few days. I promise you a response most likely via pm.

[jinx]

Great, thanks again.

[TheMercenary]

Originally Posted by jinx

Great, thanks again.

I found it but couldn't open it. I will see if we can order it.

I found these and can get these:


Journals / MEDLINE®
Title Citation
1 The clinical content of preconception care: immunizations as part of preconception care. PreviewAbstract Full Text PDF Find Similar Articles MEDLINE® is the source for the citation and abstract of this record Coonrod DV - Am J Obstet Gynecol - 01-DEC-2008; 199(6 Suppl 2): S290-5
2 Mercury exposure and public health. Review PreviewAbstract Full Text PDF Find Similar Articles MEDLINE® is the source for the citation and abstract of this record Clifton JC 2nd - Pediatr Clin North Am - 01-APR-2007; 54(2): 237-69, viii
3 Special immunization considerations of the preterm infant. Review PreviewAbstract CrossRef Find Similar Articles MEDLINE® is the source for the citation and abstract of this record Gad A - J Pediatr Health Care - 01-NOV-2007; 21(6): 385-91
Show All 3 Results

The Clinics
Title Citation
1 Mercury exposure and public health. Review PreviewAbstract Full Text PDF Find Similar Articles MEDLINE® is the source for the citation and abstract of this record Clifton JC 2nd - Pediatr Clin North Am - 01-APR-2007; 54(2): 237-69, viii

the last one is interesting and is about 45 pages long from the Pediatric Clinics of North America. I saved the PDF and can email it to you if you want. Just pm me where I can em a big assed file.

[TheMercenary]

Here are some others from Medscape:

Autism Resource Center
Autism, an early childhood condition characterized by symptoms of abnormal social interaction, communication, or behavior, is one in a group of disorders comprising autism spectrum disease. The causes of autism are unknown. Early signs of autism include unusual responses to environmental stimuli, unusual social interaction, and language delays. Behavioral, educational, and psychological therapies are the most effective autism treatments. Autism awareness and early diagnosis are crucial for effective treatment. Autism Overview
Autism Diagnosis
Autism Treatment
Autism Follow-up
Autism Pictures
Autism CME/CE


Featured Autism Articles
Do Children With Autism Experience High Rates of Gastrointestinal Problems?
A study published in the August 2009 issue of Pediatrics compares the long-term data on children with autism and those without.

Medscape Pediatrics, September 2009
Citalopram Ineffective in Children With Autism
A National Institutes of Health trial has found that citalopram is ineffective in treating repetitive behavior in children and adolescents with autism spectrum disorders.

Medscape Psychiatry & Mental Health, July 2009
Autism Medication Found to be Ineffectual in Treatment of Autistic Children
In his latest video blog, Dr. Robert Findling reports on a NIH study that finds that citalopram is no better than placebo in treating autistic children with repetitive behavior.

Medscape Psychiatry & Mental Health, June 2009
Autism, ADHD, and Medicated Births
Could the extensive use of medication during birth be contributing to the recent increase in developmental disorders?

Medscape Ob/Gyn & Women's Health, May 2009
Can Mirtazapine be Used to Treat OCD Symptoms Associated With Asperger's Syndrome?
Dr. Bethany DiPaula addresses whether Mirtazapine can be effectively used to Asperger's Syndrome patients with obsessive-compulsive disorder.

Medscape Psychiatry & Mental Health, April 2009
Body Expressions of Emotion Do Not Trigger Fear Contagion in Autism Spectrum Disorder
Emotion perception deficits in ASD may be due to compromised processing of the emotional component of observed actions.

Social Cognitive and Affective Neuroscience, March 2009
Mirror Neurons and Their Clinical Relevance
One of the most exciting events in neurosciences over the past few years has been the discovery of a mechanism that unifies action perception and action execution.

Nature Clinical Practice Neurology, January 2009
Advanced Parental Age and the Risk of Autism Spectrum Disorder
What are the effects of maternal and paternal age on risk of autism spectrum disorder?

American Journal of Epidemiology, December 2008
Impact of Innate Immunity in a Subset of Children With Autism Spectrum Disorders: A Case Control Study
This study assessed whether clinical features of ASD subset are associated with atopy, asthma, food allergy, primary immunodeficiency, or innate immune responses important in viral infections.

Journal of Neuroinflammation, November 2008
Pharmacology and Genetics of Autism: Implications for Diagnosis and Treatment
What is the current state of the molecular genetic causes of autism? How can we extend the pharmacological principles pioneered in fragile X and Rett syndromes to the broader group of autism patients?

Personalized Medicine, November 2008
Autism Spectrum Disorder-associated Biomarkers for Case Evaluation and Management by Clinical Geneticists
The authors provide a brief cataloging of the rapidly emerging, clinically available biomarkers that the clinician can use to evaluate autism spectrum disorders.

Expert Review of Molecular Diagnostics, November 2008
Autism Spectrum and Psychiatric Comorbidities
What psychiatric conditions occur most often in patients with autism spectrum disorders? In his latest video blog, Dr. Robert Findling discusses the most common presentations.

Medscape Psychiatry & Mental Health, September 2008
California Data Do Not Support a Link Between Thimerosal in Vaccines and Autism
A study published in the January 2008 issue of the Archives of General Psychiatry looks at California Department of Developmental Services data.

Medscape Pediatrics, August 2008
New Developments in Autism Spectrum Disorders
Eric Hollander, MD, Professor and Chairman of Psychiatry; Director, Seaver and New York Autism Center of Excellence, NY, describes the newest information on autism.

The Medscape Journal of Medicine, June 2008
Abnormal Cerebral Effective Connectivity During Explicit Emotional Processing in Adults With Autism Spectrum Disorder
These study provides evidence that abnormal long-range connectivity between structures of the 'social brain' could explain the socio-emotional troubles that characterize the autistic pathology.

Social Cognitive and Affective Neuroscience, June 2008
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases
Can chronic bacterial or viral infections be a common feature of progressive neurodegenerative and neurobehavioral diseases?

Laboratory Medicine, May 2008
Rett Syndrome: From Recognition to Diagnosis to Intervention
This review details the clinical picture of Rett syndrome and the diagnostic strategies required, explores the critical medical issues and recent advances in molecular neurobiology, and provides an overview of intervention strategies.

Expert Review of Endocrinology and Metabolism, May 2008
Thimerosal in Vaccines: Some Reassuring Data
Whether thimerosal increases prevalence of autism remains controversial even though most vaccines no longer contain this preservative. Has there been a decrease in reported autism since its removal?

Journal Watch, January 2008
Thimerosal in Vaccines and Neuropsychological Outcomes?
A study published in the September 27, 2007 issue of NEJM fails to find a link between prenatal or postnatal thimerosal exposure and neuropsychological functioning in childhood.

Medscape Pediatrics, January 2008
Highlights of the 115th Annual Meeting of the American Psychological Association
Why is it more difficult to treat anxiety than depression in children? How can you prevent adolescent suicide? What psychosocial interventions are best in later life?

Medscape Psychiatry & Mental Health, January 2008
More

Guidelines and Summary Guidelines
Scottish Intercollegiate Guidelines Network - Assessment, diagnosis and clinical interventions for children and young people with Autism Spectrum Disorders
American Academy of Neurology - Screening and Diagnosing Children With Autism
American Academy of Pediatrics Guidelines - American Academy of Pediatrics Guidelines 2007
Ohio Developmental Disabilities Council - Service Guidelines for Individuals With Autism Spectrum Disorder/Pervasive Developmental Disorder (ASD/PDD)
Practice parameter: screening and diagnosis of autism. Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society
Practice parameter: evaluation of the child with global developmental delay: report of the Quality Standards Subcommittee of the American Academy of Neurology and The Practice Committee of the Child Neurology Society

[Clodfobble]

A retrovirus (similar to HIV) has been tentatively connected to autism:

Last week, researchers from the University of Nevada, the National Cancer Institute and The Cleveland Clinic announced the startling discovery of antibodies to a little known retrovirus in 95% of patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating neuro-immune disease impacting more than a million people in the United States.

...

Researchers tested blood samples from a "small group of children" with autism and found that 40% of them were positive for XMRV, according to a statement from the Nevada Commission on Autism Spectrum Disorders. More testing is underway which, the Commission said, "could dramatically increase that 40% positive finding." (Given the small sample size, such a statement is purely speculative).

...

"On that note, if I might speculate a little bit," she said, "This might even explain why vaccines would lead to autism in some children, because these viruses live and divide and grow in lymphocytes -- the immune response cells, the B and the T cells. So when you give a vaccine, you send your B and T cells in your immune system into overdrive. That's its job. Well, if you are harboring one virus, and you replicate it a whole bunch, you've now broken the balance between the immune response and the virus. So you have had the underlying virus, and then amplified it with that vaccine, and then set off the disease, such that your immune system could no longer control other infections, and created an immune deficiency."

[xoxoxoBruce]

these viruses live and divide and grow in lymphocytes -- the immune response cells, the B and the T cells. So when you give a vaccine, you send your B and T cells in your immune system into overdrive. That's its job. Well, if you are harboring one virus, and you replicate it a whole bunch, you've now broken the balance between the immune response and the virus.

So is it a matter of timing, introducing the vaccine before the virus has been defeated?
If the virus is never defeated, and it's a never ending battle, then wouldn't any infection, anything the immune system is called on to battle, cause the virus to spread?

[TheMercenary]

Originally Posted by xoxoxoBruce

If the virus is never defeated, and it's a never ending battle, then wouldn't any infection, anything the immune system is called on to battle, cause the virus to spread?

I think that is a bit of a stretch. Much of that thinking is theoretical.

[Clodfobble]

In theory, yes, just like a normal disease can set off Type 1 diabetes in a child predisposed to it. But the vaccine's adjuvants throw the whole system into a far larger response than it normally would give to any real infection. So the chances of a vaccine causing the virus to spread are much higher than an appropriately-modulated immune response to a normal pathogen. Not to mention that in the real world, you don't usually get Diptheria, Tetanus, Pertussis, Hepatitis B, and influenza all in the same day.

[xoxoxoBruce]

Ahhh, OK. Thank you.